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When a reporter and her cameraman follow Los Angeles firemen into an apartment building in response to a distress call, they and the residents are locked inside by the CDC with a vicious infection spreading through the building.Television reporter Angela (Carpenter) and her cameraman, Scott (Harris), are covering the goings-on at a firehouse for a program about night shift workers. An alarm sounds and a truck is dispatched - with Angela and Scott on board - to an apartment building where an old woman has seemingly lost her mind. The woman bites one of the firemen and is soon killed, but when more tenants turn up with the same disorder, it's clear that a chain reaction is occurring. Unfortunately for Angela and the rest of the uninfected residents, the authorities have quarantined the building - but she and Scott continue to document the tragic and terrifying events inside the building as those inside are one by one transformed into bloodthirsty monsters.

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